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However, when given in a later stage of established pressure load, sildenafil reduced fibrosis and reduced ventricular stiffness [ 44], supporting the concept that timing and loading severity determines cardiac response (Fig. 3).
Therefore, one of the main aims of the present study was to characterize the CII-specific T cell response in CIA over time analyzing four general stages of disease course: 1) the initial phase of CIA with no visible signs of disease, 2) the stage when joint inflammation become apparent, that is, disease onset, 3) the stage of established disease, and 4) the chronic phase of CIA.
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At the early stage of establishing an entrepreneurial team, the start-ups mainly drew upon identity-based networks, such as fellow students, researchers, or job colleagues.
Because the study aimed to look at how parents engage in early intervention from the very beginning, my aim was to find families who were at the very earliest stage of establishing early intervention services at the time of recruitment.
Now China is under the initial stage of establishing competitive electrical market, real time price mechanism is not yet implemented, and it will need a long time to be perfect.
While the Bush administration failed to act on the reports the Obama White House is now in the final stage of establishing a U.S. National Ocean Policy that follows their recommendations on how to improve the stewardship of our public seas.
An additional stage of establishing validity of the IAPSQ was the pre-testing of the questionnaires.
This could be a good accomplishment for the initial stage of establishing smoke-free policies.
CH provided statistical consultation and chose the best statistical modeling method for outbreak detection in the initiation stage of establishing the ED-SSS.
However, up to date, very few works have gone beyond the descriptive stage of establishing what types of microorganisms may be found in specific microenvironments [ 13], thus explaining the incipient biotechnological applications derived from knowledge that still being gained.
The most important strategy to minimise this problem is to physically separate the areas used for preparing the PCRs and handling PCR products and this should be taken into consideration at an early stage of establishing a molecular diagnostic laboratory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com