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RTT girls develop normally until 6 18 months of age when they enter a stage of developmental arrest.
We speculate that the double positive subset likely corresponds to progenitors in a stage of developmental transition as this population is not retained in adult brains.
Meanwhile, Brd2-null animals survive implantation and die at a later embryonic stage of developmental abnormalities unrelated to maintenance of the inner cell mass (Shang et al., 2009), confirming our results that Brd2 is not essential for ESC state maintenance.
A detailed staging of individual embryos allows composition of a homogenous sample of embryos at a particular stage of developmental progress (e.g. for quantitative or comparative studies in wild type and mutant mice), or of ranking the embryos in a series of detailed step-by-step developmental stages to trace the dynamics of a specific event.
Gene-set enrichment analysis using the ToppCluster tool (Kaimal et al., 2010), which analyzes enrichment for each of these compartment-specific signatures (as well as to other biological datasets such as GO terms and phenotypic data sources), was used to further analyze the stage of developmental block in the different mutants.
Similar(53)
The temporal aspect has not been given explicit attention in the artificial development community, apart from defining intermediate or final stages of developmental processes, after a defined number of time steps [5].
With a few notable exceptions, human and animal model studies tend to focus on the end stages of developmental abnormalities.
Recruitment of newly originated genes at early stages of developmental might allow evolution of specific phenotypes, while conserved genes retain function for the conserved core of development.
Similar to the follicles beyond the germarium, cysts within the germarium are morphologically arranged in a predominately linear fashion in increasing stages of developmental maturity.
However, our finding that most of the wheat NRAMP genes were not DE during wheat senescence suggests that these transporters may act in other tissues or stages of developmental stages.
Studies from a number of years ago showed that the VEGF pathway is central and absolutely essential for early stages of developmental angiogenesis; these findings helped drive the development of VEGF inhibitors for clinical use (Ferrara, 1999).
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