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However, the mRNA levels of osteocalcin, a late stage marker of osteoblastic differentiation, was also increased (P<.05) by treatment with 1,25(OH)2D3.
Interestingly, we did not observe expression of the liver stage marker UIS4 or nuclear divisions, as seen in EEFs (Figure 5C), in the transformed puf2 sporozoites (Figure 6A).
Interestingly, although most puf2 sporozoites eventually transform into completely round forms, these forms do not progress to EEF differentiation, as shown by minimal expression of the liver stage marker UIS4 and absence of nuclear division or growth.
Noteworthy, the expression of osteocalcin, which is a late stage marker of osteogenic differentiation, was found to be strongly increased in the presence of the Biocoral scaffold in both DPSCs and osteoblasts, with respect to their controls during the osteoblast differentiation.
Group 2 contains another primitive foregut stage marker HNF4α along-with HNF6[ 2].
The expression of the late stage marker SPP1 increased significantly during osteoinduction in OG cells.
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The unique conductivity of carbon nanotubes is being exploited by a number of researchers around the world to make selective tests for early stage markers for cancer, as well as for cancer cells themselves.
However, at BC3F3 stage, marker-assisted background analysis was performed on multiple QTL-near-isogenic lines (NILs) selected for maximum phenotypic similarity with the RP.
In AD model mice, abnormal expression of EphA4 and EphB2 are detected much earlier than the decrease in synaptic proteins and the onset of cognitive decline (Simón et al., 2009), indicating that Eph receptors may act as early stage markers of AD.
In contrast, fatty acids such as palmitate are later stage markers of impaired glucose regulation, and only distinguish NGT-IS from IGT subjects in the continuum of insulin resistance.
The function as stage markers has been confirmed on the same genotype for an additional growing season (Additional file 3).
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