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These QC flags give users the opportunity to e.g. only select those distribution records that have complete abundance information available or where the life stage is documented.
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Tumour length, size (using RECIST criteria) and stage were documented and numbers and size of locoregional lymph nodes recorded.
The transcripts related to cuticle formation that were up-regulated in the post-moult stage when compared against the intermoult stage, are documented in Table 3.
The factors that were independently significant, after adjustment for the others, are the retrospectively assigned FIGO stage category (P<0.0001), whether adjuvant radiotherapy was used (P=0002) and whether the patient's FIGO stage was documented (P=0.0022).
Two clinically important prognostic factors were found to be associated with survival; whether the International Federation of Obstetrics and Gynaecology stage was documented, RHR=2.0 (95% CI=1.3 to 3.1) and also to the use of adjuvant radiotherapy, RHR=2.2 (95% CI=1.5 to 3.5).
Consequently the three stages were documented in parents only.
Staging was documented according to the criteria of the Seventh American Joint Committee on Cancer (AJCC) 13.
Thus it is likely that these are genuine differences in survival, representing the association between staging being documented and of adjuvant radiotherapy being used.
High statistical correlation between MCAM/MUC18 intensity and both Breslow thickness and AJCC stages was documented via Spearman's rank correlation test.
Cancer staging was documented by treating doctors as either Tumour, Nodes and Metastasis (TNM) scores, American Joint Committee on Cancer Staging Scores (I - IV) [ 10] or as localised cancer, regional spread or metastatic disease; for comparability, TNM and AJCC scores were converted to localised/regional/distant spread using commonly accepted cut- points.
The project team will ensure that an audit trail of decisions made at each stage in the study is documented so that the decision-making process can be scrutinised.
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