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Interestingly, the amount of total dollars being invested at the seed stage has remained roughly the same.
Nonetheless, whether global DNA hypomethylation influences cancer progression to a more advanced stage has remained uncertain.
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Among the plethora of changes observed at metamorphosis is the terminal differentiation of neurons, which, until that stage, have remained dormant since the time they arose in embryonic or larval neurogenesis.
The role of the hypothalamic suprachiasmatic nucleus (SCN) in the circadian gating of sleep and wakefulness has been unequivocally established by lesion studies [5], but its role in the timing of specific sleep stages has remained unknown.
The molecular biology of the clinically silent pre-erythrocytic stages of mammalian Plasmodium spp, composed of both the sporozoite and liver stages, has remained largely uncharacterized.
However, their earliest formative stages have remained a matter for speculation because they have not been caught this early in the process of formation.
Overall survival (OS) is thus short (5-year OS: 30 40% for all stages) and has remained stable for two decades, notably in advanced stages (McGuire et al, 1999).
Although advancements in diagnosis, screening and awareness help identify BC at an early stage, optimal management has remained a challenge due to its histological and molecular heterogeneity [ 2], and varying response to therapies even within clinical subtypes of BC [ 3].
Despite developments in surgery, chemotherapy and radiotherapy, the long-term survival of patients with metastatic and higher staging breast cancer has remained very low.
Two-stage exchange arthroplasty has remained the gold standard in the treatment of infected total knee arthroplasties (TKAs) for over two decades (Leone and Hanssen 2006).
The exoerythrocytic stage of Plasmodium falciparum has remained a difficult phase of the parasite life-cycle to study.
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CEO of Professional Science Editing for Scientists @ prosciediting.com