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The grade (based on the proliferation rate) and stage (extent of disease) of this tumor were coincident.
Covariates were: centrally reviewed Gleason grade, baseline PSA value, clinical stage, extent of disease (proportion of positive cores), age at diagnosis, and initial hormone management.
Covariates evaluated were centrally reviewed Gleason score, baseline PSA value, clinical stage, extent of disease (proportion of positive chips), age at diagnosis and Ki-67 score (% cells positive).
According to tumour stage, extent of liver cirrhosis and other clinical factors, different treatment options were chosen in this study as indicated in Figure 1.
Covariates included centrally reviewed Gleason score, baseline PSA value, clinical stage, extent of cancer (proportion of positive cores), age at diagnosis, and Ki-67.
In the multivariate analysis, patient age, serum prostate-specific antigen level, clinical T stage, extent of disease on bone scan, and biopsy Gleason sum were independent prognostic factors.
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Current treatment stratification is based on patient age, M-stage, extent of initial surgery, and histopathological subtyping.
The relationship of TPH1 staining to progression was clearest among samples sorted according to N-stage (extent of lymph node involvement).
Additional characteristics included age, gender, Karnofsky performance score (KPS), pre-radiotherapy hemoglobin levels, tumor site, histological grading, human papilloma virus (HPV -status, T-classification, N-classification, American Joint Committee on Cancer (AJCC)-stage, extent of resection and concurrent cHPV -status.
In addition to clinical parameters, plain radiographies in two standard planes (one when weight bearing) and MRI scans (T1 weighted, T2 weighted and short T1 inversion recovery (STIR) weighted) were performed for radiographic analysis by a blinded independent radiologist (DB) (parameters: ARCO stages, extent of BME: progression, persistence, regression).
Imaging features of the stage and extent of tumours including features which indicate unresectability and knowledge of the role of endoscopy and endoscopic US (DK).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com