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Aside from adverse stage distribution, to what extent might differences in practice related to surgery, radiotherapy or chemotherapy account for observed differences in outcomes between Britain and the countries in Europe with the best survival rates?
Under our approach, we calculated estimates for men using their own stage-specific survival, while matching only the overall stage distribution to that of women (using the same approach when calculating the deprivation estimates).
Other studies of HL survivors (Wolden et al, 2000; Castiglioni et al, 2007) have found that radiation-related BCs have a similar stage distribution to that of primary BC, which is consistent with our findings.
Figure 2 shows the number of deaths that can be postponed beyond certain points during the follow-up period by achieving earlier stage distribution in the three older age groups (i.e., by matching their stage distribution to that of women aged 70 74 years within the same deprivation groups).
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The relationship between mammography and stage distribution at diagnosis seemed to be the relationship with greatest variation in published values and greatest potential impact on model outputs.
The reduction in breast cancer mortality is related to more favourable stage distribution and to improved breast cancer specific survival rates overall and by stage, presumably due to better treatment and breast cancer care.
Instead, FIGO stage distribution at presentation was analyzed to determine if this was influenced by BAF250a loss, PIK3CA, or ARID1A mutation status.
The percentage of missing liver fibrosis stages was greater than 10%% in the patients bearing HCV genotypes 2, 3, and 4. The secondary analysis was performed to assess the HCV genotype and liver fibrosis stage distribution according to previous HCV therapy (Fig. 3).
The distribution of tumour stage at diagnosis revealed a decreasing proportion of tumours with regional or distant metastasis with increasing years of education up to 13 16 years, whereas the highest educated women had a stage distribution similar to the middle educated (10 12 years of education).
Therefore, the analysis proposed in the present paper shows that the reactive/permeative stage distribution has to be considered an important reactor design parameter, which can be opportunely modified to improve the performances of the process.
We started each simulation with a population at stable stage distribution according to the specific habitat type.
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