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Gene expression analyses indicate that HGF coating enhanced osteoblast differentiation as demonstrated by increased runx2 (a transcription factor important for osteoblast lineage and differentiation), alkaline phosphatase (marker of mid stage differentiation) and osteocalcin (marker of late stage differentiation) mRNA levels.
We observed that the stiffness of chondroid cells increased continuously in the late stage differentiation, reducing cell deformability and perhaps causing cell degeneration.
Although this interconnectivity is present in every developmental stage, differentiation proceeds with concomitant increase in chromatin compaction and re-distribution of condensed chromatin toward the nuclear core.
Azetidinone 1, 2E and 2Z led to a moderate effect in decreasing SH-SY5Y cell proliferation and β-lactams 2E and 2Z induced an early stage differentiation.
Trypanosoma cruzi, the etiological agent of Chagas disease, uses proline as its main carbon source, essential for parasite growth and stage differentiation in epimastigotes and amastigotes.
For Plasmodium falciparum, the etiological agent of malignant tertian malaria, sexual stage differentiation (gametocytogenesis) from asexual parasites occurs in the blood of the human host.
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The two-stage differentiation flowshop consists of a stage-1 common machine and m stage-2 parallel dedicated machines.
Osteoblastic cells had a high rate of proliferation on all examined films and expressed alkaline phosphatase activity, an early-stage differentiation marker.
This paper addresses the total completion time minimization in a two-stage differentiation flowshop where the sequences of jobs per type are predetermined.
This assay failed to detect any newly translated insulin in an ES cell-derived population generated using an adapted version of a previously published, 5-stage differentiation protocol.
The late-stage differentiation marker, GPDH activity, was increased by PCB-77.
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