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Inclusion of information in the filing, i.e. stage dependence, placement, materials/reagents prior to route disclosed also discussed.
In order to check for stage dependence of the lethal effect, we injected dsRNAs targeting these 11 genes into ten adult beetles, respectively.
The previous observation of stage dependence in relation to the prognostic potential of a specific CXC-chemokine's expression raises several important considerations.
A second consequence of these considerations is that the developmental "stage dependence" is a very important concept of DNT AOPs and needs to be considered for the selection of positive and negative control substances for test systems.
In comparison with budded cells, Hsp104-GFP retention was significantly reduced at all temperatures when unbudded cells were exposed to elevated temperature, but the magnitude of the effect was most severe for conditions that induced curing (30°C→40°C and 37°C→40°C; Figure 5A, orange), indicating a cell-cycle stage dependence on Hsp104-GFP retention at elevated temperature.
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As a comparison, the surface structure of the passive film formed at −0.4 V for 30 min exhibited two-stage dependence on air exposure time, distinctly different from that of the air-formed films, and its passivity showed two-stage dependence on air exposure time.
For E. coli we make predictions about the growth-stage dependence of the spatial arrangement of the chromosome.
Here we focus on the photic circadian and other rhythm-stage dependence of changes in 1-minute TE and on any effects of age.
In order to understand the staging dependence of both G-line components, we have to add the effect of lattice expansion and of charge transfer.
The developmental stage-dependence of the CSF flow pattern was examined to detect the stage at which CSF flow is produced.
This immediately rationalizes the stage-dependence of biomarker validation: both biomarkers failed to stratify the two least-powered stages (IA and III - there are only 68 stage III patients), but were successful in the two better-powered stages (IB and II) and in the overall cohort.
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CEO of Professional Science Editing for Scientists @ prosciediting.com