Exact(2)
In case of early stage degenerative disc disease or traumatic herniations, a suitable treatment may be to replace the nucleus pulposus, preserving the annulus fibrosus.
In humans with low back pain due to end stage degenerative disc disease, spinal fusion using cages with or without pedicle screw fixation is currently the state-of-the-art [ 23– 25], rather than decompressive surgery alone.
Similar(58)
Metal-on-metal hip resurfacing systems offer an alternative treatment to standard total hip arthroplasty in patients who have end-stage degenerative hip disease.
Total hip arthroplasty provides pain relief and restores function to millions of older patients with end-stage degenerative joint disease [ 6, 18, 34].
Thus, histological variables identified as risk factors of ESRD typically reflect either active inflammation or the late-stage, degenerative consequences of inflammation.
Our results suggest that DH tissue resorption may be even more dependent on MMP-3 than end-stage degenerative IVD tissue.
Current research attempts at investigating disc degeneration have focused on models thought to represent the late-stage degenerative changes [ 6- 16].
Metal-on-metal hip resurfacing systems offer an alternative treatment to standard total hip arthroplasty in patients who have end-stage degenerative hip disease and who have failed non-operative management [ 1- 3].
Total joint replacements, which represent the current standard of care for end-stage, degenerative hip and knee disease, typically incorporate a metal or ceramic component articulating against a counterface of ultra-high molecular weight polyethylene (UHMWPE) [ 1].
A 47-year-old male presented with end-stage degenerative disc disease at L2/3 with associated severe back pain and bilateral lower extremity radiculopathy that had failed an extensive course of nonoperative management.
Acute herniations occur in the early stage of degenerative disease when intradiscal pressure is still relatively high.
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