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The adjusted survival curves for each GOLD stage, adjusted for age, sex and selected co-morbidities are presented in Figures 1 and 2, for the old and the new classification, respectively.
Transmission risks did not differ between 59 SDNVP-exposed and 782 unexposed women in unadjusted analysis or after adjustment for viral load and disease stage (adjusted odds ratio 0.6, 95% confidence interval [CI] 0.2 to 2.0).
Also, patients in advanced WHO stage compared to those in less advanced stage (adjusted HR = 2.8, 95% CI = 1.6, 4.8) and those having TLC less than or equal to the median value were more likely to die (adjusted HR = 1.6, 95% CI = 1.01, 2.42) during the pre-ART period.
Image acquisition and FRAP were performed using either a Bio-Rad MRC1024/Zeiss Axiovert M135 confocal microscope equipped with a cooling/warming stage adjusted to reach 10°C in the observation chamber (Lauda Ecoline Staredition RE106; Lauda-Königshofen, Germany), or a Zeiss LSM510 confocal microscope set at 20°C, 30°C or 37°C (XL/LSM incubator, Zeiss).
Being in less advanced WHO clinical stage (adjusted HR = 1.9, 95% CI = 1.6, 2.2), being in the recent cohort compared to being in early phase (adjusted HR = 2.0, 95% CI = 1.6, 2.6), and being a rural resident (adjusted HR = 1.8, 95% CI = 1.5, 2.2) were independent predictors of loss to follow-up.
Gender, age and pubertal stage adjusted both multivariable models (linear regression and binary logistic regression).
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As shown in Tables 2 and 3, both fibrinogen and EBV DNA are associated with DFS TNMM stage-adjusted HR: 1.81, 95% CI: 1.45 to 2.26 for top fibrinogen tertiles; TNM stage-adjusted HR: 4.79, 95% CI: 3.33 to 6.89 for top EBV DNA tertiles; both compared with the bottom tertiles).
This study will use the two-stage adjusted analysis based on cluster summaries developed by Hayes and Moulten (2009, pp182-184) [ 47].
A list of genes and their stage-adjusted hazard ratios and Cox proportional hazards model P-values and q-values (adjusted for multiple testing using FDR) are listed in Table S1.
In the Austrian study, women still had a survival advantage in an age- and stage-adjusted model [ 21], while in Korea, women's higher risk of death disappeared after adjusting for age and stage [ 22].
We obtained data from 760 elderly patients in stage-adjusted groups and collected 244 RCTs from the National Comprehensive Cancer Network (NCCN) and 148 from the European Society for Medical Oncology ESMOO) guidelines.
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