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Thirty HIV positive volunteers receiving a stable regimen of antiretroviral therapy with CD4 counts >400 were recruited for the safety evaluation of LFn-p24C, a detoxified anthrax-derived polypeptide fused to the subtype C HIV gag protein p24.
Quante et al. (2010) investigated 23 inpatients with Diagnostic and Statistical Manual of Mental Disorders-4th Edition (DSM-IV -diagnosed bipolar major DSM-IV -diagnosedton DSM-IV -diagnosed scale (HAM-D) ≥ 20) with a pre-existing stabipolarimajorf lithium or valproate for at least 1 week.
All patients continued to receive a stable regimen of MTX (≥15 but ≤25 mg/week).
Patients are allowed to continue their psychotropic medication if they stay on a stable regimen throughout the intervention.
Each of these study protocols stipulated that patients would continue a stable regimen of baseline immunomodulator therapy throughout study participation.
Although this is in line with directives, frequent changes to therapy before a stable regimen is reached suggest that pain relief with tolerability are difficult to achieve.
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METHODS:We conducted a randomized double-blind placebo-controlled withdrawal study in patients with LEM who had been on stable regimens of 3,4-diaminopyridine base (3,4-DAP) for ≥ 3 months.
Subjects using antiretroviral therapy (ART) were required to be on stable regimens for at least 30 days before enrollment and were asked to remain so during the study.
In addition to its well-characterized effects on lipid metabolism, colesevelam also produced consistent modest incremental reductions in A1C of up to 0.8% in addition to LDL cholesterol reductions of up to 17% when given to type 2 diabetic subjects inadequately controlled on stable regimens of metformin, sulfonylureas, or insulin (6– 8).
Chronic hemodialysis patients on stable regimens of epoetin alfa were sequentially assigned to cohorts that differed on (1) how the peginesatide starting dose was determined (using a single epoetin alfa to-peginesatide dose conversion ralfa to-peginesatideight-basedose absolute-dose conversion table) and on (2) whetherationor a 1-week erytierediesis-stimulating agent-free interval was used.
Subjects were required to be on a stable medication regimen for at least 3 months prior to entry and were continued on the same regimen during the study.
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