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American video artist Bill Viola, in whose work water is a stable participant, fell into a lake at the age of six and saw "probably the most beautiful world I've ever seen".
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Using 20 stable participants, test-retest reliability was good for all domains (ICC =.76 .85).
Reproducibility assesses whether stable participants (based on responses on the OTE) scored similarly on the GSRS and GIQLI from Baseline to Visit 2. Hays and colleagues[ 11] suggest that intraclass correlation coefficients (ICCs) should be greater than 0.60 in stable participants.
In the present study we assume that the most stable participants were those in the expert group.
For metabolically stable participants (i.e., no episode of diabetic ketoacidosis during the previous month), fasting blood samples were drawn after a minimum 8-h overnight fast.
Blood was drawn from metabolically stable participants (no episodes of diabetic ketoacidosis [DKA] during the previous month) after a minimum 8-h overnight fast.
Once stable, participants were admitted to the inpatient unit for 3 days of post-testing, which consisted of repeating all baseline tests.
These numbers were too small to allow separate analysis of variability in "stable" participants but do raise the possibility of true change in participant status as a significant factor underlying intra-observer variability.
In addition, the reproducibility of the OPSAT-Q scales was assessed using both Pearson's and intra-class correlation coefficient estimates among stable participants over a 1 to 2 week period.
In light of this, we must consider that our population-specific estimate of minimal detectable change could be inaccurate, and we recommend that in future, this method of retrospectively identifying stable participants is generally avoided.
Guyatt's index of responsiveness is then calculated by dividing this MID by the square root of twice the mean square error (MSE) of stable participants (people who rate interval change as "the same").
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com