Exact(1)
In their simulation, Hathaway et al. chose k∗ to be low compared to propagation and turnover but not so low that stable marks had not appeared by the time nucleation was stopped.
Similar(59)
But with politicians in Germany already having second thoughts about the treaty's plans to replace the powerful and stable mark with a more amorphous Euro-currency, and constitutional arguments raging there and in France, opposition to the treaty elsewhere could get a powerful boost now that Danes have rejected it.
Since DNA methylation is a highly stable mark, the bond between a methyl group and cytosine ring being one of the most stable chemical bonds [18], the differences in methylation are unlikely to be a consequence of conditions immediately preceding death or during the postmortem interval.
H3K9me3, on the other hand, is associated with DNA methylation and is a stable mark, denoting permanent silencing [ 58, 59].
In contrast, lysine methylation appears to be a more stable mark, with what appears to be a more complicated readout (reviewed in Zhang and Reinberg, 2001; Lachner, 2002).
This is likely to happen once the inherently bounded domain is established, unless the stabilisation rate, k∗, is so low that no stable mark has appeared.
Emerging evidence from the initial stages of cancer development suggests that the patterns of DNA methylation, a stable mark capable of transcriptional control, are deregulated early and may serve as a predictor of malignant potential [ 19, 21, 5].
5-Methylcytosine and methylated histones have been considered for a long time as stable epigenetic marks of chromatin involved in gene regulation.
This is a heady position to be in and no matter that one-day rankings are from the same stable that marks the England football team down as being the world's third best side.
They serve this purpose because the relative abstractness, comprehensiveness, and concentration of the verbal expressions of beliefs enable them to serve better than most other forms of religious symbolism as stable identifying marks in pluralistic, changing, proselytizing, and missionary situations.
Interestingly, previous study had indicated that the stable repressive marks (H3K9-me3 and H3K27-me3) remained unchanged upon 5-Aza-dC treatment.
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