Exact(8)
Isoprostanes are stable markers of oxidative stress.
In an environment of ceaseless flux, it is important to identify stable markers and to hold fast to them.
Focusing on the main cellular producers of these cytokines, such as circulating monocytes and macrophages, may be a better approach to find stable markers for BD.
For this reason, stable markers, so called endophenotypes, are of primary interest.
Slowly-evolving but stable markers such as SNPs could be useful for this purpose, but are difficult to identify due to the monomorphic nature of North American isolates.
This could partly explain the discrepancy of the results but if MCP-1, EGF and VEGF are to be used as stable markers of stress, they should be able to discriminate patients from controls even in smaller groups.
In this regard, classical genotyping using more stable markers might prove useful.
Using genetic mutations as stable markers of evolution, we reconstructed the phylogenetic lineage of the tumor.
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