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8-Oxo-7,8-dihydrodeoxyguanine (8-oxoG) is a stable marker of DNA damage.
Methods: Intestinal epithelial cells were transduced with the green fluorescent protein gene as a stable marker by lentiviral transfection.
A marker that is positive some of the time and negative other times is not a stable marker and therefore not considered significant.
The purpose of this investigation was to evaluate oxidative stress in plasma from diabetic rats and their fetuses through measurement of concentrations of 8-isoprostaglandin F2α, a stable marker of lipid peroxidation.
On the other hand, the intermediate filament protein Vimentin is frequently overexpressed and contributes to cell migration as well as invasion-associated gene expression by stabilizing the phosphorylated state of MAPK and is thus regarded as a stable marker of EMT; moreover, its presence is a prerequisite for the maturation of invadopodia which are indispensable for cell invasion [32, 54, 55].
In this type of studies, the tested strain is mixed with a reference strain, which differs in an easy-to-score and genetically stable marker, and allowed to compete for a limited common pool of resources during a given number of generations.
Similar(10)
Isoprostanes are stable markers of oxidative stress.
In an environment of ceaseless flux, it is important to identify stable markers and to hold fast to them.
Focusing on the main cellular producers of these cytokines, such as circulating monocytes and macrophages, may be a better approach to find stable markers for BD.
For this reason, stable markers, so called endophenotypes, are of primary interest.
Slowly-evolving but stable markers such as SNPs could be useful for this purpose, but are difficult to identify due to the monomorphic nature of North American isolates.
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