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Since DNA methylation is a highly stable mark, the bond between a methyl group and cytosine ring being one of the most stable chemical bonds [18], the differences in methylation are unlikely to be a consequence of conditions immediately preceding death or during the postmortem interval.
H3K9me3, on the other hand, is associated with DNA methylation and is a stable mark, denoting permanent silencing [ 58, 59].
In contrast, lysine methylation appears to be a more stable mark, with what appears to be a more complicated readout (reviewed in Zhang and Reinberg, 2001; Lachner, 2002).
This is likely to happen once the inherently bounded domain is established, unless the stabilisation rate, k∗, is so low that no stable mark has appeared.
Emerging evidence from the initial stages of cancer development suggests that the patterns of DNA methylation, a stable mark capable of transcriptional control, are deregulated early and may serve as a predictor of malignant potential [ 19, 21, 5].
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In their simulation, Hathaway et al. chose k∗ to be low compared to propagation and turnover but not so low that stable marks had not appeared by the time nucleation was stopped.
The last time, in 1955, the vote was dominated by the desire to join the German postwar "economic miracle" and have the strong, stable German mark.
DNA methylation is a heritable and stable epigenetic mark associated with transcriptional repression.
When Germany had a stable deutsche mark before switching to the euro, it did better economically than did neighboring France, with its chronically weak franc.
The German institution is guided by memories of disastrous hyperinflation in the Weimar Republic in the 1920s and the country's postwar revival under a strong, stable deutsche mark.
DNA methylation is a stable epigenetic mark associated with long-lasting silencing of gene expression [18].
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