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The interference with these functions at multiple levels may not only play a role in the control of primary infections or reactivations but can also impact other arms of the immune system and leave a long-lasting stable imprint on the NK cell population.
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Independently, HCMV induces the expansion and differentiation of killer cell immunoglobulin like receptor (KIR- expressing NKIR- expressingstiNK as stable imprints in the NK cellsrepertoire.
Such transient DMRs may be associated with parental-allele-specific or skewed allelic expression early in embryogenesis, but there is also evidence that they can give rise to stable imprinting of linked genes, although the DMRs themselves lose monoallelic methylation during embryogenesis (Duffié et al., 2014).
Theories on the origins of intra- and intertumoral heterogeneity [ 10] include: rise of subclones from precursors that subsequently accrue genetic changes; stochastic gene expression patterns generating random signaling pulses; or cellular reprogramming by semi-stable imprinting of epigenetic tags [ 11].
Similar to our findings, establishment of silencing in this model system was a slow process, and, once silenced, the transgenes retained a stable epigenetic imprint that maintained silencing [ 34].
The results reveal that the free energy landscape of the β-switch has two stable conformations imprinted on it, namely, loop and hairpin with flow inducing a transition between the two.
The stable proteins molecularly imprinted polymers (MIPs) films were fabricated by electropolymerization using l-cysteine (L-Cys) as functional monomers and BSA as templates.
Sex-specific genomic imprinting and stable female X-inactivation are also under epigenetic control.
Cytosine DNA methylation (mC) is involved in a range of important biological processes, including silencing of repetitive sequences and transposable elements (TEs), genomic imprinting, and stable gene silencing.
Some have noted, for instance, that Random House's Del Rey imprint has a stable of science-fiction and fantasy writers that could elevate the narratives of games within those genres.
Depending on the most stable configuration, hydroxyzine and cetirizine imprinted polymer models were designed.
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