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Moreover, fluorescence recovery after photobleaching (FRAP) analysis show that association of TRAF4 with the TJ is not a stable event but a highly dynamic process.
Aberrant DNA methylation is usually an early and stable event in tumorigenesis and could be used for detecting and monitoring diseases [ 32].
Mortality is low in this group of type 1 diabetic individuals with substantial disease burden, with stable event rates during the 12-year period (Fig. 3 A ).
This suggests that the production of TNFα and IL-1β is an early and relatively transient process, rather than a prolonged and stable event, such as glial activation in the AD brain, because pathological alterations, including Aβ accumulation and glial activation, were first detected in the cortex of 5XFAD mice (Oakley et al., 2006).
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In other words, the discreteness represented by m ∈ ℤ refers to rare and possibly stable events instead of the possibly unstable continuum represented by m ∈ ℝ.
In particular, copy number alterations are stable events, not affected by cell cycle or cytokine stimulation.
From this observation they postulated the multistage theory of carcinogenesis and inferred six to seven independent, sequential and stable events occurring in the cancer lineage before malignancy became manifest.
Based on these results, we would like to mention that our C2EM architecture has the ability to handle the uncertainties about complex events and provides a reliable and stable complex event monitoring service.
These findings consolidate our preliminary data in colonic polyposis (Marotta et al, 2001) and indicate that this dysregulation is a stable reproducible event in multistage colon carcinogenesis.
And, we track TF molecules through time/frames and, for each stable binding event, we only count once with the average localization over multiple frames.
Due to mechanical constraints of the targeted epigenetic editing machinery, it is unlikely that a single and even very stable binding event would lead to a widespread modification at larger distances.
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