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We tried to minimize this impact by requiring a stable dose for six months prior to study inclusion.
Methods: Galanin was administered to 10 patients with depression, who were on a stable dose of trimipramine.
Patient 3 was on a stable dose of pregabalin 300 mg/day and nortriptyline 30 mg/day at baseline, with marginal benefit.
Treatment, if needed, was at their psychiatrists' discretion, but it was recommended the use of a stable dose during the study's period.
All patients had been on a stable dose of a mood stabiliser and/or antidepressant at an adequate dose for at least 8 weeks prior to study entry.
Alternatively, opioids such as methadone can often be used as a stable dose in severe patients without any problems.
Patients taking riluzole were included if they were on a stable dose for at least 30 days before enrolment (for further details on patients, see Table 1).
Oral mesalamine was continued at a stable dose.
Patients received furosemide in a stable dose throughout the study.
Three patients were on a "statin" stable dose.
Methotrexate, at stable dose, was continued throughout the study.
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