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The qualitative interpretation resulted in a classification of stable diseases in all five cases with no perceptible difference in uptake or number of lesions (Figure 1).
Moreover, in patients with metastatic renal cell carcinoma that were previously treated with a VEGFR tyrosine kinase inhibitor and an mTOR inhibitor, dovitinib treatment resulted in two partial responses (3.6%) and 29 stable diseases (52.7%) in a phase-II setting [12].
Different variables were tested for their influence on CBR in which stable diseases (SD) were included.
The combined percentages of objective responses and stable diseases (SD) amounted to a clinical benefit rate (CBR) of 54% in prostate cancer and 48% in RCC.
Best responses were partial or stable diseases.
There were two stable diseases but no progressive disease.
Only stable diseases were observed in TA7/TA7 patients receiving IRI.
The second strength was the third-part CT-scan review that confirms stable diseases.
The disease control rate was 39.4 %, including one partial response and 12 stable diseases.
There were 4 partial responses (PR) and 4 prolonged stable diseases (SD) [33].
Disease control (three partial responses, 29 stable diseases) rate was 72%95%5% CI 57 83%).
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