Such events initiate stable changes in gene expression without changing nucleotide sequences [ 63].
Although the suspension alone was stable, changes in pH, particle agglomeration rate and hydrodynamic diameter in nanoparticles occurred in presence of wheat and pumpkin plants.
Monocyte training by β-glucans was associated with stable changes in histone trimethylation at H3K4, which suggests the involvement of epigenetic mechanisms in this phenomenon.
Second, altitude exposure might induce stable changes in phenotype, perhaps through epigenetic modifications.
Cells were returned to the incubator (37°C) for 2 h, which we determined to result in maximal and stable changes in fluorescence.
We describe for the first time a link from prolonged ERK activation to stable changes in genome organization through redistribution of heterochromatic domains involving the telomeres.
DNA methylation patterns which are largely established in-utero, induce stable changes in gene expression that may be sustained throughout the life span of an individual [33].
Signals were amplified using Axoclamp-200B amplifiers and collected only when the series resistance was relatively stable (changes were less than 30% of original).
We have previously observed that cell density can increase the gene expression noise and induce epigenetic effects leading to stable changes in gene expression [10].
This suggests that CD3 treatment induces stable changes in signaling to Rac, perhaps by decreasing the activities of proteins that normal turn off Rac activity, including GAPs or GDIs [9].
In rodents, for example, variations in maternal care during the early postnatal period produces modifications of chromatin and demethylation of DNA within offspring brains which in turn are associated with stable changes in gene expression, brain development, and behavior [6].
