Sentence examples for stable alteration from inspiring English sources
First identified in 1975, CpG island (CGI) methylation was shown to function as a relatively stable alteration on DNA that can serve to silence gene transcription (Holliday and Pugh, 1975; Riggs, 1975).
This enables U2585 to form hydrogen bonds with C2606 and G2588, which should lead to a fairly stable alteration of the PTC.
This suggests that the stable alteration of the microbiome specifically influences its future ability to maintain healthy host-microbe metabolic interactions.
Similar results were found at different time points for several patients (data not shown), suggesting that CRT exposure reflects a stable alteration of blasts.
[ 7] Our results suggest that this regulatory mechanism also occurs in vivo, and that the stable alteration of miRNA as a result of neurodevelopmental teratogenesis may affect long-term gene expression of its target transcript(s) long after exposure.
To further investigate the effect of p.G223V mutant ACD on telomere structure, we performed a TRF assay (Fig. 2c) and showed that decreased apoptosis correlates with increased telomere length in Nalm-6 ACD G223V at both tested passages compared to Nalm-6 ACD WT and Nalm-6 pLenti (P =0.029, Mann–Whitney U test), confirming stable alteration of telomere homeostasis.
In contrast, emerging evidence suggests epigenetics (e.g. DNA methylation, RNA associated silencing and histone modifications) is involved in the ability of environmental experiences to regulate the genome and to develop stable alterations in phenotype [3].
This programming may involve stable alterations in gene expression states, mediated by epigenetic modifications.
Stable alterations in DAG metabolism in hypothyroid liver are suggested to lead to disturbances in agonist responsiveness of liver cells.
Epigenetic modifications of DNA convey stable alterations in gene expression, not mediated by changes in DNA sequence.
More recently, epigenetics was redefined as the study of "stable alterations in gene expression without alterations in the genetic code itself" [ 6].
