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Taxol is known to function by binding the inner surface of microtubules and stabilizing them in their polymerized state [2], [5].
Gic1 interacts with specific subunits within adjacent septins, and these interactions have the effect of crosslinking the septins and stabilizing them in long filaments.
Thanks to the numerous lateral hydrophobic side groups, these short soluble polymers associate with the transmembrane surface of MPs, rendering them soluble in aqueous solutions in the absence of detergent while stabilizing them in native-like functional states.
Collectively, these investigations indicate that the Smc5/6 complex promotes HR-dependent rescue of stalled replication forks by stabilizing them in recombination-component configurations and by facilitating the resolution or preventing the formation of certain recombination intermediates.
Laulimalide is a macrolide isolated from marine sponge (Cacospongia mycofijiensis) which inhibits cell proliferation, promoting assembly of the microtubules and stabilizing them in a taxol-like way, but at a different binding site located on two adjacent β-tubulin units between tubulin protofilaments of a microtubule [ 198– 200].
Similar(55)
Interestingly, Sdf1 slightly stabilizes protrusions in single cells and strongly stabilize them in groups.
However, such results are not surprising since polyamines will interact and bind with such molecules, stabilizing them into aggregates when in solutions.
The ropes eased the opening and closing of the sashes and stabilized them in a fixed position.
This material consists of graphene sheets which are chemically functionalized with groups such as hydroxy and epoxide, which stabilize them in water.
Why the binding of a variety of substrates can drive the transportation cycle, while inhibitor binding may stabilize them in only one of their two possible conformations.
They must quickly appraise a sick person's situation and emotional state, calm down agitated patients and stabilize them in difficult situations, and carry out certain procedures that patients find unpleasant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com