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In this paper, we examine outputs from the smart education research community and the ITLET standards community to identify how evolving conceptual frameworks could inform specification work stabilizing the core terminology (e.g., as in smart technologies) in order to promote innovation.
For example, zinc chloride restores p53 wild-type conformation, stabilizing the core domain.
Thus, three properties indicate that I148T/L267P and W275S GOF mutations act by stabilizing the core gating mechanism of the channel to promote the conductive conformation of the selectivity filter: the large increase in channel activity, the resistance to changes in [K+]O, and the similarity of the pHO response to that of the wild-type channel in high external potassium.
Although the atomic level structure and the heterogeneity of the contacts stabilizing the core of protofibrils formed by each Aβ variant are unknown, Aβ43 protofibrils are morphologically similar as determined by microscopy to those we have previously observed for Aβ42 and Aβ40.
Residues along the central spine of the solenoid and the CTD have low temperature factors, consistent with their role in stabilizing the core of the molecule, whilst N and C-terminal regions beyond the CTD display higher B-factors for solvent-exposed residues, implying greater flexibility (Fig. 1C).
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Second, the glue builds up a fillet which stabilizes the core and increases the buckling load.
Researchers writing today in Nature Medicine used a two-step method: They introduced a combination of mutations to stabilize the core of the hemagglutinin stem.
Through interacting with RBBP4 and SUZ12, AEBP2 stabilizes the core PRC2 complex, thus significantly increases the HMTase activity of PRC2 (Cao and Zhang, 2004).
The inverse will happen near the CMB: denser Fe will snow downwards in the core and leave the outermost liquid richer in S. If convection is not vigorous enough, the stratification could stabilize the core into compositionally distinct layers, in which convection occurs only in the steadily shrinking well-mixed central zone.
Alyx and Gordon re-enter the now-decaying Citadel to try to stabilize the core; Gordon is successful in re-engaging the reactor's containment field, which delays the explosion.
We rationalized that the binding of NTD125 to p53-CTD might stabilize the core domain that, in turn, enhanced p53-DBS binding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com