Sentence examples for stabilizing the closed from inspiring English sources

And the simple interpretation would be, you must be really stabilizing the closed state by increasing the charge density of the head group layer.

Agonists, usually small, induce closure of the binding pocket, leading to opening of the channel pore, whereas antagonists, usually large, induce opening of the binding pocket, thereby stabilizing the closed pore.

That the C-terminal mutants shifted the VDA suggests that the C-terminus contributes to activation gating mechanism by stabilizing the closed state or destabilizing the open state without affecting the kinetics of activation.

These data are most consistent with dephospho-threonine at this position stabilizing the closed state.

However, it does increase the number of dispersion interactions with the nearby W93 residue, thus stabilizing the "closed" conformation.

The V5L and I36L mutants, although initially identified as stabilizing the closed substate, were revealed by umbrella sampling simulations to have almost no effect on the substate populations.

This crucial property enables its application to sensor faults in unstable plants, where existing data-driven filter designs could not be applied so far due to the lack of such stability guarantees (even after stabilizing the closed-loop system).

The fault-tolerant controller is designed to compensate for the effect of faults by stabilizing the closed-loop system under the actuator failures.

The correct incoming dNTP triggers Fingers closing and stabilizes the closed ternary complex, allowing proper alignment of the substrates prior to nucleotidyl transfer.

Findings from this study revealed that the inhibitor stabilized the closed conformation and reversed the open conformation to a low ICAM-affinity state (closed) as evidenced by the upward movement of the α7 helix and corresponding transitions at the active site.

Suzuki, T., Hansen, A. & Sanguinetti, M. C. Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2.1 potassium channels.