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Apart from adhering to the extracellular matrix, cell-cell adhesions also play an indispensable role in stabilizing the cellular and tissue structure.
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To accelerate the logical drug design procedure, we created the program "NAGARA," a plugin for PyMOL, and applied it to the discovery of small compounds called medical chaperones (MCs) that stabilize the cellular form of a prion protein (PrPC).
Cardiac IK1 stabilizes the cellular resting membrane potential and is responsible for shaping both the initial depolarization and the final repolarization of the action potential [ 31, 32].
Fixation of the cells to be analyzed is important to cross-link and stabilize the cellular structure in preparation for permeabilization and access of the phosphospecific antibody to their targets, although the exact percentage of paraformaldehyde (range 1 4%) used for this procedure does not seem to be of great importance.
It stabilizes the cellular level of lysosomes and replaces deficient endogenous hormones that decrease inflammation in the body.
The method involved dissolving of the cell membrane lipids, eliminating the cell cytoskeleton with trypsin, digesting the cellular RNA and stabilizing the chromatin with spermine.
Neuronal tau is an important protein in promoting and stabilizing the microtubule system involved in cellular transport and neuronal morphogenesis.
However, given the unique function of P-proteins and forisomes, it is possible disulfide bridges could form when the redox state of the cytosol is disrupted by cellular damage, stabilizing the dispersed state of SEO proteins and allowing them to seal off the injured sieve element.
We show that FG repeats are highly dynamic IDPs, stabilized by the cellular environment.
We speculate from these findings that sorbitol may play a crucial role in cellular protection, by stabilizing the membrane bilayer or involving membrane fluidity, and by recovery of the cells from the stress.
The relationship between E-cadherin and β-catenin is well studied and together these molecules stabilize the epithelial polarized cellular shape.
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