Sentence examples for stabilizing the active from inspiring English sources

FAp phase plays important roles of dispersing the active species on its surface to have high catalytic activity and of stabilizing the active species to lead to high reusability.

Starting from these observations, we rationally designed variations of the parent sequence aimed at stabilizing the active fold, and consequently increase aptamer activity.

However, biochemical characterization showed that the presence of the SH2 domain is frequently required for catalytic activity, suggesting a crucial function stabilizing the active state of many nonreceptor tyrosine kinases.

The R1275 side chain contributes to direct interaction between activation loop helix and the α ´ C helix, stabilizing the active conformation of active ALK tyrosine kinase domain conformation.

Residues mutated in (A ) are involved in stabilizing the active dimer, whereas residues in (B ) couple the dimer formation to the opening of the activation segment.

So, a common theme between activating the procaspase versus inhibiting the mature caspase appears to involve stabilizing the active site loops through interactions in the allosteric site or reversing the process respectively.

These residues play critical parts in positioning ATP, stabilizing the active-conformation and in the catalytic mechanism.

However, provided that this histidine residue is protonated (p Ka 6.6±1.0), it should also be capable of stabilizing the transition state oxyanion and of stabilizing the active-site loop.

These results are consistent with the idea that PKA activity stabilizes the active wakefulness state.

The data suggest that an efficient activator must stabilize the active conformer of the zymogen by expelling the intersubunit linker from the interface, and it must interact with active site residues found in the allosteric site.

There is ample experimental evidence to show that GPCRs exist in an ensemble of conformations and binding of agonists, and the intracellular signaling proteins, such as the trimeric G-proteins, cooperatively activate and stabilize the active state of the receptor.