Sentence examples for stabilizing modifications from inspiring English sources

DNA aptamers are heat and protease resistant without stabilizing modifications.

We have combined Z-DNA stabilizing modifications with a strong nucleosome positioning sequence to assemble mononucleosomes on Z-DNA.

From this perspective, another approach to designing fast but stable cycloaddition substrates is to start with compounds such as DIFBO (7) and selectively eliminate their unwanted reactivities through the introduction of stabilizing modifications.

For improving the stability of aptamers, pyrimidine as well as purine nucleotides can be modified at their 2′ positions and tested for their ability to accommodate stabilizing modifications like 2′-O-methyl groups [ 47].

Vitreous state stabilizing modification with Sb additives reduces outer free-volume shell of positron trapping sites mainly due to shielding effect from more metallic environment.

This may serve as further support of our predictions of the tRF regulatory function since in these mutants the disrupted stabilizing modification, lack of tRF RISC loading, and subsequent deregulation of the neuronal targets could further contribute to such phenotypes.

We then combined this stabilizing modification with ring contraction, an activating feature previously unexplored in the context of Cu-free click chemistry, and identified a known thiacycloheptyne that is stable under ambient conditions but reacts with model azides faster than any reported cyclooctyne.

This again illustrates how alternative conformations of local torsions stabilized through modifications of the environment contribute to larger scale structural changes such as base flipping.

Structural modifications stabilizing P-form helices may obviate the need for large heterocycles to target DNA pyrimidine bases via PNA·DNA-PNA triplex formation.

This supports widespread H3K27me3 signals together with loss of active histone modifications stabilizing a silent chromatin conformation after differentiation.

The nanoporous PS thin film template was stabilized by modification of substrate using hydroxyl terminated PS so as to enhance the adhesion with substrate for following electroplating process.