To determine whether USP52 regulates HIF1A stability through stabilizing its 3′-UTR, we used a Renilla luciferase reporter construct fused to the HIF1A 3′-UTR.
These chaperones function by binding to the enzyme and stabilizing its fold, allowing it to reach its site of activity, i.e. the lysosome.
β-Gal from E. coli is only active in its tetrameric form [16], and it may be that YHNN and QYHH enhance the activity and stability of β-Gal by stabilizing its tetrameric structure.
terms might be eased or offset by European Union assistance once Iceland was able to show it was committed to stabilizing its economy and paying its debts.
But the dream lives, and so for that matter does Metromedia, which today announced that it has made some progress toward stabilizing its funding situation.
While Dell doesn't dispute the analysis either, it notes there's a payoff in strengthening and stabilizing its staff.
It is possible that monoubiquitylated Tollip interacts with the receptor stabilizing its sumoylation.
For example, the E3 mediatesiates p53 regulation via the UPP (Moll and Petrenko, 2003), but it can also bind to the p53 relative protein, p73, stabilizing its levels (Ongkeko et al., 1999).
"The company reacted by restructuring, downsizing and stabilizing its financial division".
By some measures, Portugal is making good progress in terms of stabilizing its economy and getting public debt under control.
We illustrate these ideas with a program calledFixPoint, which improves its performance over time by stabilizing its environment.
