Its side chain stacks with the nucleotide base, stabilizing it in its position.
eEF1A1 then associates with elongating RNA polymerase II and the 3′UTR of HSP70 mRNA, stabilizing it and facilitating its transport from the nucleus to active ribosomes.
For example, in Xenopus, the cycling of MELK depends on its phosphorylation during M-phase, stabilizing it, whereas dephosphorylation of MELK coincides with its degradation [10].
Furthermore, TRF2, via its highly-basic N-terminus, interacts with 4-way junction DNA [41], increasing its rate of formation and stabilizing it in a unique conformation, thereby inhibiting junction resolving activities [44].
The Trp-cage offers unique function to exenatide by stabilizing it further against enzymatic degradation, and enhancing its in vivo potency.
The first described autoantibody was C3Nef, which binds to a neoepitope on the C3 convertase of the alternative pathway component C3bBb, stabilizing it against CFH-mediated decay and prolonging its C3 cleaving action (Fig 7).
In short, when the Federal Reserve Board talked in late June about "labor and product markets that are stabilizing," it was making an important point -- in its characteristically obscure and understated manner.
However, due to its instability under physiological conditions, efforts were directed towards stabilizing it by grafting a hydrolysable carbamate onto the 3-position.
Mr. Leonik's leg has 15 long screws stabilizing it, and scars from knee to hip.
The glaring lesson of the war is that American ground invasions destabilize the Middle East, instead of stabilizing it.
As for the Balkans, after more than 20 years of operations, NATO has still not succeeded in stabilizing it.
