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Exact(35)
Structural evidence (Sarafianos, S.G., personal communication) supports the specific affect of the K65R substitution on catalysis; in the absence of the stabilizing interaction between the 3'OH and the β phosphate of the nucleotide, R65 interacts instead with the α phosphate and the R72 residue, directly affecting catalysis.
The proteins were designed from first principles (de novo) using current knowledge about membrane insertion and stabilizing interaction motifs.
Bands appearing due to phosphorus and carbon bond stretching shifted to 1384 cm−1 and became more intense which suggests the stabilizing interaction of phosphine group with gold nanomaterials.
The need for an aglyconic aryl group was rationalized by molecular modeling calculations, which have emphasized a high stabilizing interaction of this group by stacking with W312 of the enzyme.
The modeling suggests a critical stabilizing interaction between the pore helix and the selectivity filter that is absent in wild-type KCNQ3 and the A315V mutant, but present in the A315T and A315S mutants.
Our results show that there is a significant stabilizing interaction between the Pd dπ orbital and the vinyl vinyl hybrid σ∗/π∗ orbitals in the reductive elimination transition structure.
Similar(25)
It may simply reflect that it is harder to identify stabilizing interactions in proteins with intrinsically higher stability.
N120 also provides stabilizing interactions with the RNA phosphate backbone contributing to RNA stability, though probably not specificity (Table 2).
Additional, experimentally selected mutations quenched conformational heterogeneity through new stabilizing interactions.
Boundary organizations play an important role in stabilizing interactions between science and nonscience.
The latter is related to the mean hydrophobicity when the protein is largely unfrustrated with regard to its stabilizing interactions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com