Type 2 diabetic individuals with stabilized dose of medication, age 30 to 70, with Glycated Hemoglobin A1c (Hbetweenetween 6 and 12 %, Fasting Blood Glucose (FBG) <15 mmol/l and Body Mass Index (BMI) between 18.5 and 40 kg/m, were eligible to join the study (the levels of BMI and HbA1c extended from the initial plan due to the difficulties fulfilling the sample size).
Of 406 randomized patients, 244 comprised the evaluable-for-efficacy population (⩾12 weeks of treatment and stabilized topiramate dose during final 28 days); 213 were on topiramate monotherapy at the end of the trial.
The mean stabilized daily dose of topiramate over the last 28 days of treatment (primary endpoint) was significantly lower for patients reporting one to three seizures (low seizure frequency, n = 147) than for those reporting more than three seizures (high seizure frequency, n = 66) during a 3-month retrospective baseline period (191 mg vs 239 mg, P = 0.003).
This 24-week, multicenter, open-label trial was designed to evaluate the dosing, effectiveness, and safety of topiramate monotherapy for epilepsy and to identify patient and clinical characteristics predictive of optimally effective stabilized monotherapy doses.
Up to 90% receptor occupancy has been measured at stabilized clinical doses of buprenorphine.
The drug is observed to impart a stabilizing effect at low doses and a destabilization above a saturation level at the polar regions of the lipids.
25 The 52-week parallel-group study observed patients treated with alogliptin 25 mg plus pioglitazone 30 mg plus metformin (≥1,500 mg or stabilized maximally tolerated dose, n=404) versus an up-titration of pioglitazone to 45 mg with stable metformin dosing (n=399).
Low dose stabilized haemoglobin solution has potential utility in the treatment of global ischaemia-reperfusion injury though further work is needed to clarify optimal dose and mechanism(s) of action.
The telomere length was almost stabilized in later dose groups from high level natural radiation areas.
The Bz-induced quiescence was stabilized by low dose (500nM) of 5-azacytidine (Aza) pre-treatment, which also potentiated the initial Bz-induced apoptosis.
