Moreover, bisphosphonates are mainly antiresorptive agents, which are inhibitors of bone resorption acting mainly to stabilize bone mass and prevent further bone loss.
The longer after menopause that therapy is delayed, the more bone is likely to be lost and the less effective the hormones are in stabilizing bones.
Estrogen treatment reduced osteoclastogenesis, stabilized bone turnover, and therefore preserved alveolar bone mass in the ovariectomized rat.
Prospective data show that calcium stabilized bone [ 35].
This locks the base plate, stabilizes bone graft and increases the potential of healing bone.
Borohydride reduction of bone collagen by means of the procedure of Bailey [ 28], appears to stabilize bone collagen without affecting the bone morphogenetic property.
Zimmer, which had $1.04 billion in 2000 sales, makes joint replacements and devices used to stabilize bones.
In postmenopausal women, administration of estrogen suppresses bone resorption and produces a transient decrease in serum calcium and phosphorus and in renal reabsorption of phosphorus, as well as positive calcium balance effects that help to stabilize the total skeletal bone mass.
Intriguingly, the extracellular domain of ActRIIA stabilized by fusion to IgG-Fc increases bone mass and strength by activin inhibition, and is a novel promising agent for osteoporosis in early human trials [ 77, 78] (Table S2; Additional file 2).
These agents are capable of preserving bone mass, enhancing mineralization of the bone matrix, potentially stabilizing the trabecular microarchitecture, and reducing fracture rates.
