But in absorbing variation, such stabilizing architectures also hide it from view, and a sensitizing change in the stabilizer that shifts liability outside the zone of canalization can have a dramatic effect on the phenotype.
H1 belongs to a class of chromatin architectural proteins (CAPs) that are responsible for maintaining, modulating and stabilizing chromatin architecture.
Angiopoietin-1 is a secreted growth factor which binds to Tie-2 present on endothelia to enhance cell survival thereby stabilizing capillary architecture in-vitro.
Live-cell observations and analyses revealed that, whereas a small portion of crossover-localized augmin complexes act to trigger nascent microtubule nucleation, the majority function in stabilizing the architecture of microtubule crossovers.
Compared to globular proteins, RNAs with complex 3D folds are characterized by poorly differentiated molecular surfaces dominated by backbone phosphates, sparse tertiary contacts stabilizing global architecture, and conformational flexibility.
These preliminary results suggest that alkaline activation might be efficient in stabilizing earthen architecture, as well as other clay-rich building and ornamental materials by reducing the intracrystalline swelling capacity of smectites, limiting osmotic swelling of both expandable and non-expandable clays, and producing gel-like silicate cements.
One such target is CAMKII, which is critical for the establishment of synaptic plasticity and memory and in stabilizing dendritic architecture [28], with a specific role for CAMKIIB in targeting the alpha CAMKII isoform to dendritic spines and the cell cortex [29].
Taken together, these improved biological performances were attributed to the selection of appropriate biomaterial candidates for tuning the surface properties of the ODN nanoparticles, the stability of inherent polymeric ODN, and the use of stabilizing LbL architectures.
M CO lone pair)…π arene) interactions were found to be important in stabilizing supramolecular architectures and to lead to, usually, zero-dimensional aggregation patterns.
Like p73, but unlike p53, p63 requires a second helix (H2) to stabilize the architecture of the tetramer.
