Sentence examples for stabilizing an active from inspiring English sources

We have designed these detergents with the aim of stabilizing an active conformation of the extracted membrane proteins such as ABC transporters, and as shown in Figure 5 they indeed behave as expected.

Thus, ligands 4 and 5 stabilize an inactive ATP-binding site conformation while stabilizing an active, extended global kinase conformation.

It does so by modifying cysteine residues within both the SD and IBC and thereby stabilizing an active conformation of the IP3R.

We conclude that thimerosal selectively sensitizes IP3R1 and IP3R2 to IP3 by modifying cysteine residues within both the SD and IBC and thereby stabilizing an active conformation of the receptor.

Our previous mutagenesis of these two cysteine residues [ 12] indicate that they are not directly involved in catalysis, making it likely that they play a role in stabilizing an active form of enzyme tertiary structure.

An activation mechanism has been reported for PKN2 [ 2], whereby hydrophobic-motif interaction with the PIF (PDK1-interacting fragment -pocket ofragment -pocketr activatiof looPDK1osphorylallows and upon turn motiforhosphorylactivation C-terminaloopmain of phosphorylations from PDK1 and interacts with its own catalytic domain, stabilizing an active conformation.

For one, clustering induces intermolecular autophosphorylation, which stabilizes an active conformation of the activation loop.

Intriguingly, engagement of Fyn1's SH2 domain autoinhibits the kinase to an extent greater than that observed for Fyn2 as demonstrated by decreased catalytic activity and diminished affinity for inhibitors that stabilize an active ATP-binding site.

RGS proteins may stabilize an active GPCR/G protein/channel complex to limit the diffusion time necessary for activation and deactivation [ 11, 12].

Rather, they most likely induce or stabilize an active conformation of JAK2.

They find that the C terminus of ArfA occupies the mRNA entry channel, while the N terminus recruits RF2 and stabilizes an active conformation in the release factor, even in the absence of a stop codon.