Sentence examples for stabilizing a specific from inspiring English sources
In some cases, a metal ion can coordinate two or more groups from separate secondary structural motifs, thereby bridging domains and stabilizing a specific tertiary structure.
The precise function of the kinase-inhibitor Necrostatin-1 is well established that this molecule is an allosteric inhibitor of RIPK1, stabilizing a specific inactive conformation of the kinase domain.
These clients are structurally highly diverse, and co-chaperones are important for the interaction of Hsp90 with different clients 7. Different co-chaperones bind to Hsp90 in a progressive manner, each stabilizing a specific conformation of Hsp90 and directing the conformational cycle which allows client activation 8.
Their results suggested Cys141 plays a role in the final steps of the catalytic mechanism by either transferring a hydrogen atom to the allylic methyl radical of repaired TpT or stabilizing a specific state of the enzyme preventing side reactions with exogenous molecules.
Some of the products investigated were not intended to stabilize antibodies, or were specifically made to stabilize a specific nucleic acid (e.g., DNAstāble was not intended to stabilize RNA).
Here we will discuss our view of how agonist binding within the large ECD triggers the necessary change of conformation, or stabilize a specific conformation, of the heptahelical domain leading to G-protein activation.
We interpret these findings to indicate that the FLL residues in transmembrane domain 4 stabilize a specific conformation that attenuates or regulates FIT2 activity.
MTANs also stabilize a specific water molecule adjacent to C1′ as the incipient nucleophilic group.
Ubiquitin binding might therefore be expected to stabilize a specific reciprocal orientation of the N-lobe subdomains.
Taken together, our results indicate that nucleotide binding induces conformational changes within ORC that are propagated throughout the entire complex to stabilize a specific structural state.
Now, Bleichert et al. have found a way to stabilize a specific conformation of Drosophila ORC, and have gone on to determine its structure at a higher resolution than was previously possible.
