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Co-repressors, such as N-CoR and SMRT, form complexes with deacetylases that modify histone tails, thereby stabilizing a more compact chromatin state.
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Thus, our data suggest that the ATP-mimicking ADP·BeFx and ATPγS analogs stabilize a more 'closed' conformation.
This interaction stabilizes a more compact form of the HHRz and supports higher in vitro rates while lowering the Mg2+ dependence of folding to increase in vivo rates as well.
According to the Hadley model, that could mean world temperatures stabilizing at a more than 3˚C increase.
Mrs. Johnson Sirleaf came out on top in the first round of voting in October, shortly after having been named the joint winner of this year's Nobel Peace Prize for her efforts in stabilizing a country torn by more than a decade of civil war.
A further challenge is to recognize key residues, termed as hotspots, at protein protein interfaces, which contribute more in stabilizing a protein protein interface.
In both cases, higher propensity of the leader sequence to fold into the shunt-supporting configuration, with stem section 1 stabilized by a more stable (and/or compact) structure above, might account for increased efficiency of shunting.
In both cases, the DNA must be stabilized in a more functional conformation.
However, its oral use has been described in non-life-threatening infections where the patients had already been stabilized with a more potent agent [ 54].
With increasing concentration of Cu, zirconia is stabilized more and more in the cubic phase than in the tetragonal phase.
A reasonable interpretation of this result is that the TMAO stabilizes a conformational ensemble that more closely approximates that of the wild-type enzyme, providing a more substrate-accommodating binding site than the structure with an unfolded LD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com