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According to the authors such compound should form stabilize interaction between NBD1 and ICL4, which is suspected to be altered in ΔF508-CFTR and causes folding defect (Mendoza et al, 2012; Rabeh et al, 2012).
In an alternative model, does S90 phosphorylation stabilize interaction of the Beclin 1/VPS34/ATG14 complex with membranes, similar to a previously suggested model for ATG14 regulation (Fogel et al., 2013)?
The missense change of aspartic acid to glycine at position 606 interrupts the side chain side chain hydrogen bond Asp606OD2 Arg595NH1 without affecting other hydrogen bonds that stabilize interaction between C6 and D6 β-strands (Fig. 6B, inset).
The presence of small amounts of salts such as ammonium sulfate contributing both ammonium and highly charged sulfate ions, may stabilize interaction between TaqII and SIN; these latter molecules apparently form a complex with different properties than those of the natural TaqII-SAM complex.
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Only a few salt bridges stabilize interactions between adjacent subunits (intersubunit salt bridges) and thus are important for stabilization of the quaternary structure.
Binding of Npl3 to the nascent transcript might stabilize interactions between the CTD, RNAP II and the RNA and prevent premature 3' end formation.
The functions of Atrn and Mgrn are not as well understood, although Atrn is thought to stabilize interactions between Mc1r and Agouti [11].
In animal tetraspanins, these conserved polar/charged amino acids are thought to stabilize interactions between transmembrane domains [ 10].
The nearly invariant Glu residue in subdomain III helps stabilize interactions between the Lys residue and ATP (Hanks and Hunter, 1995).
Value of α is varied between zero and one until we get stabilized interaction values for 10000 interactions.
The proteins were designed from first principles (de novo) using current knowledge about membrane insertion and stabilizing interaction motifs.
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