Exact(3)
The hapten was designed to induce an antibody binding site with both a base and an acid, in position to initiate proton transfer and stabilize developing negative charge at the phenoxide leaving group, respectively.
The latter include for example hydrogen bond acceptors and donors for proton abstraction and proton donation, positive charges to stabilize developing negative charge in the transition state, etc.
Thus, endothelial α-pv seems to stabilize developing vessels by maintaining the integrity of VE-cadherin junctions.
Similar(56)
The pronounced differences in the Brønsted plots comparing R (TA and GC) and W (TG and GT) pairings suggest that the base mispairs result in a change in the active-site conformation to the detriment of the bonding interactions available in the vicinity of the triphosphate group of the nucleotide that promote catalysis by stabilizing developing charge on the leaving group in the TS.
The global economy will not stabilize until developing economies do, and their destabilization journey has just started.
DBU or MTBD act as Brønsted bases and are proposed to help stabilize the developing fluoride ion, rendering it available to nucleophilic reaction.
From these results and previous findings, we propose that Meltrin β negatively regulates ephrin-A5-EphA vesicular internalization, which could be one of mechanisms to stabilize the developing NMJ.
However, the differences between the leaving groups are mainly determined by the extent to which they can stabilize the developing negative charge.
Intravenous bolus injections of wild-type PAI-1 (wPAI-1) markedly inhibit fibrinolysis in a dose responsive manner in vivo and stabilize a developing thrombus [ 10, 18– 218.
Although the establishment of vascular cell fate, differentiation, and new vessel formation has been extensively investigated, the mechanisms that stabilize the developing vasculature are less understood.
Because of the relative proximity of Zn2 to O2 (3.79 ± 0.32 Å), it is conceivable that Zn2 could further polarize the lactone bond as well as stabilize the developing negative charge on the leaving group oxygen (O2) during ring opening.
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