Sentence examples for stabilization of the core from inspiring English sources

A comparison of the conservation profiles of the tyrosine recombinase N-terminal DBD and the ALOG domain revealed a shared pattern of hydrophobic residues in all the four helices, which are critical for the stabilization of the core tetrahelical fold.

The second conserved motif EXXR (located at position b in fig. 1) and the third consensus PER (located at position c in fig. 1) form E R R triad that is important for locking the heme pocket into position and to assure stabilization of the core structure (Deng et al. 2007; Kelly et al. 2009).

In the evolutionary model of GIR1, misfolding has been promoted by the loss of the 5′ exon that has driven the J8/7 from GIR1 to form a pseudo P1 that expanded to form P15. It is noteworthy that this process gives rise to the double pseudoknot (P3 P7 and P3 P15) that contributes to the energetic stabilization of the core of the ribozyme.

Either mechanism is possible, because the disulfide-stabilized interface is located within, rather than between, core units, but stabilization of the native core unit structure could increase the density of assembled core units on the membrane and thereby shift the equilibrium toward assembly of larger core unit oligomers and arrays.

The disulfide bridges are positioned along the interior of the protein, forming a central core, and undoubtedly conferring structural rigidity by stabilization of the protein core.

This phenomenon may arise because disulfide bonds usually result in stabilization of the hydrophobic core of protein.

Previous work on disulfide stabilization of the gp120 core has identified multiple double-cysteine mutations that minimally alter the antigenic profile of gp120.

The E-R-R triad is generally thought to be involved in locking the heme pocket into position and to ensure stabilization of the conserved core structure [ 17].

From the RIG-I and MDA5 crystal structures, the pincer domain likely contributes to maintaining the architecture of the hel domain in addition to its role in allosteric stabilization of the ATPase core [ 57].

Another motif called the E-R-R triad is thought to be important for locking the heme pocket into position and to assure stabilization of the conserved core structure.

Although preliminary studies reported reduced development of advanced coronary atherosclerosis or stabilization of the necrotic core size with selective inhibition of Lp-PLA2 by the inhibitor darapladib, 2 recently completed phase III trials did not provide evidence in favor of inhibiting Lp-PLA2 in cardiovascular disease.