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These advances have now resulted in a situation where stability, turnover numbers, and price of the catalysts have become the major issues.
They are known to influence their stability, turnover, and chemical/physical properties.
Post-translational modifications (PTMs) affect the stability, turnover, interaction potential, and localization of proteins within the cell.
Reviewed by de Bie and Ciechanover [ 15], there are many mechanisms by which stability, turnover, substrate affinity and ubiquitination are controlled.
In a plethora of examples, the artificial substitution of one or more amino acids in a polypeptide resulted in a significant increase or decrease of stability, turnover rate or substrate specificity for the enzyme (4).
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Recent studies of ubiquitination and deubiquitination in regulation of Rho GTPases stability and turnover have unveiled additional important regulatory mechanisms.
Despite this potential, they often exhibit poor stability, low turnover numbers and typically require electron transport protein(s) for catalysis.
Additional efforts are required to fully characterize the effects of this mutational pattern on TRAF6 protein stability and turnover.
The stability or turnover of mRNAs for some σ factors is for instance affected by specific nucleases.
These results indicate that the charge conferred by phosphorylation at S184 significantly reduces Bax's stability to turnover.
Furthermore, these estimates do not take into account any differences in protein stability or turnover in the cell that would influence cellular metabolic processes [71].
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