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Different regulatory guidelines recommend establishing stability profile of pharmaceuticals at the time of drug development.
The overall physical stability profile was summarized in an empirical phase diagram.
Two lead formulation candidates were selected based on their predicted stability profile.
The physical stability profile of SM4-AC as a function of pH and temperature was monitored using a combination of biophysical techniques and the resulting physical stability profile was visualized using an empirical phase diagram.
The new formulation shows an attractive stability profile both, as an aqueous suspension or a freeze-dried powder formulation.
This situation points to electronic and topologic nucleotide's backbone interactions control of the stability profile of paromomycin RNA complexes.
Sequences were selected that conformed to a consensus internal stability profile (ISP) associated with active RNAi, and RNAi triggers were expressed in the context of an endogenous miRNA.
All these features together with their adequate stability profile render these nanocapsules a new attractive platform for anticancer intracellular drug delivery.
Evaluation of the biophysical properties of a selection of humanised Fab fragments in a number of assays allowed us to select the molecule with the optimal stability profile.
A stability profile over the most commonly used pH range was established that may serve as a reference for column scouting during method development.
The objective of the present study was to report the stability profile of novel antimigrain drug Eletriptan hydrobromide based on the information obtained from forced degradation studies.
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