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Moreover, we show that AcrB within a SMALP scaffold is significantly more active than the equivalent DDM stabilised form.
The antibody detects a stabilised form of the protein that, if not stabilised through mutation, is stabilised through other means, which results in an interruption of the degradative pathway of wild-type p53 (Wynford-Thomas, 1992).
Here we have created a novel mouse CPC model by expressing a stabilised form of c-Myc (MycT58A) and inactivating Trp53 in the choroid plexus of newborn mice.
Thus we replaced LucF by LucF+ (a stabilised form of LucF) in all bicistronic vectors, resulting in an approximate 10-fold increase in LucF activity (data not shown).
In the second set of experiments, to study the effect of BPT on the stabilised form of tubulin, cells were pretreated with 10 nM paclitaxel for 30 min.
This does not appear to be the cause of the polarity phenotype, however, as the overexpression of a stabilised form of Arm has no effect on epithelial organisation (supplementary material Fig. S1E-G).
Similar(52)
Clearly a greater understanding of macrophage function in the plaque, their plasticity (or lack thereof) and the pathways involved is required to ensure that a plaque stabilising form can be promoted.
But marriage, as we all know, is a beautiful journey of discovery that can last a lifetime – or, if you are less fortunate, a series of blind-sidings that leaves you each perpetually wrong-footed and desperately casting about for stabilising forms and light weaponry with which to regain your balance and upper hand.
Indeed, although a natural physiologic precursor of endogenous sulfated compounds, SAMe in its native form degrades rapidly and only stabilised synthetic forms have been used in scientific studies [ 12].
As the reformation stabilised, Cranmer formed a committee in December 1551 to restart the work.
In biological solutions, it is stabilised by forming complexes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com