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No objective response was recorded and 8 patients (36%) had disease stabilisation (Table 3).
Interim results of trials of oral ridaforolimus for advanced endometrial cancer suggest ridaforolimus provides a response rate similar to that of everolimus but with a higher rate and a slightly longer duration of disease stabilisation (Table 4) (Colombo et al, 2007; Mackay et al, 2011; Oza et al, 2011b; ARIAD Pharmaceuticals Inc., 2012).
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Hence, HBSs containing exclusively t-connections result in the lowest and complex tape or layer structures result in the highest internal stabilisation contributions (Table 4).
Also, because of the likely influence of pMHC stability on T cell activation, we measured the stability of peptide binding by H-2Db using an RMA-S stabilisation assay (Table 1).
A larger proportion of patients treated in the first line setting achieved disease stabilisation: 40 vs 26% (Table 4-wrap>).
Baseline haemodynamics were assessed under conscious resting conditions or following stabilisation of 2% isoflurane anaesthesia (Table 1).
Image acquisition from all subjects did not require any restraint or stabilisation on the passive motion table as all subjects were able to tolerate the full 80° arcs relaxed and in comfort.
Quality of life (Table 4) and weight stabilisation were similar in both arms.
In the case of polymeric stabilisers, the typical stabilisation mechanism is based on steric stabilisation.
In contrast, neither complete or partial tumour regression nor any tumour stabilisation were observed beyond the third passage (Table 1 and Figure 1).
A total of 4 out of 29 evaluable patients (13.8%) receiving dasatinib 70 mg PO b.i.d. had partial responses by RECIST (Table 4), and 17 patients had stabilisation of disease for a clinical benefit rate (ORR+SD) of 72.4%.
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