Sentence examples for stabilisation of target from inspiring English sources

By using positive control cell lines with known truncating mutations, we have determined the optimal concentration of caffeine that results in significant stabilisation of target genes, which is suggestive of successful inhibition of the nonsense-mediated mRNA decay pathway.

We then performed semi-quantitative real-time reverse transcriptase (RTPCR) of SMAD4 to confirm stabilisation of the target gene after caffeine treatment, and cRNA from four randomly selected replicates were then hybridised to the Illumina HumanHT-12 v3 gene expression arrays.

We repeated the GINI experiments a total of three times for the BRCA1 and BRCA2 cell lines, and each replicate of every cell line showed at least a 1.5-fold stabilisation of their respective target genes after treatment with 7.5mM caffeine.

However, upon addition of the AR agonist DHT, we observed a clear thermal stabilisation of AR indicative of target engagement (Fig. 1b,d).

The highest level of target gene stabilisation in the LCLs was 2.4-fold at 7.5mM caffeine.

HIF-1 α stabilisation leads to the transcription of target genes involved in growth of blood vessels such as VEGF, inducible nitric oxide synthase, fibroblast growth factor and matrix metalloproteinases.

Supposedly, the translocation of axin leads to stabilisation of β-catenin and target gene transcription [ 24].

Engineering and economic system changes for reducing GHG emissions and revert the rapid speed of climate change are promising, but insufficient to meet the climate stabilisation targets of the Sustainable Development Goals (SDGs).

HIF1 α stabilisation results in transcriptional regulation of a variety of target genes, including the proangiogenic factors vascular endothelial growth factor and PDGF (Koukourakis et al, 2006).

MiR-29 has previously been linked to stabilisation of the p53 protein by targeting p85 α (Park et al, 2009).

First, world leaders have to agree on a target for the stabilisation of greenhouse gases in the atmosphere at a sufficiently low level to stave off dangerous climate change.