Microtubule stabilisation was enhanced in PC3 cells following treatment with combined reovirus/docetaxel combined therapy which may, in part, explain the mechanism of synergy.
As yet, they are not for sale; the company wants to first develop computer stabilisation to enhance the safety of the jetpack for inexperienced fliers.
By comparing the activity of 12.1 and Arf37 expressed as free peptides (unconstrained) or presented by CI2 (constrained), we show that scaffold-mediated stabilisation significantly enhances the activity of small peptides.
The upregulation of p53 seemed to reflect protein stabilisation rather than enhanced gene transcription, as no increase in p53 mRNA levels was detected by RT PCR in Apollon downregulated cells.
We propose semi-transparent PVs (Dye-Sensitized solar Cells, DSCs) as alternative greenhouse glazing that, compared to conventional greenhouse glazing and currently marketed greenhouse integrated opaque PV materials, offers advantages including enhanced thermal stabilisation and similar or improved edible biomass yields.
TA modules that are active and functional in surrogate cloning hosts may also generate bias in metagenomic libraries by enhancing stabilisation of constructs (such as metagenomic clones) harbouring them.
The toxin's ability to enhance stabilisation of the protein structure is further evidence of toxin binding, in addition to the observed spectral changes of the native protein at 25 °C with and without TTX.
Experimental studies have established that the stabilisation of the ternary complex is enhanced by the presence of high levels of CH2FH4 (Moran and Scanlon, 1991).
Jab1/CSN5-dependent stabilisation of HIF-1 α is enhanced by MIF, leading to the subsequent activation of hypoxia-responsive genes (Bozza et al, 1999; Honma et al, 2000; Gregory et al, 2006; Winner et al, 2007; Rendon et al, 2009).
We show that despite similar reovirus replication in p53+/+ and p53−/− cells, stabilisation of p53 by Nutlin-3a significantly enhanced reovirus-induced apoptosis and hence virus release and dissemination while having no direct effect on virus replication.
c Axial-contrast enhanced CT image of the chest after haemodynamic stabilisation shows a large amount of high-density fluid, compatible with blood (yellow arrow), in the cavern and the tracheobronchial tree.
