To identify the proteins modulated by SRF in GI smooth muscle, a proteomic analysis of Srf KO and WT jejunum smooth muscle at PT15 was performed using multidimensional protein identification technology.
Substitution rates of SRF and MEF2A-D genes in the human and mouse genomes are presented in Figure 2. From the figure, mSRF (referred to as SRF in mice) evolves faster than its corresponding orthologous hSRF (referred to as SRF in humans).
The function of SRF in macrophages had not been investigated until our previous studies revealed that SRF regulates both general and cell type-restricted cytoskeletal gene expression programs in these cells [ 26].
To analyze whether SRF directly influence the level of CYLD, we treated CYLD+/+ MEFs with siRNA against SRF in the presence of serum and found that reduction of SRF levels caused a significant down-regulation of CYLD (Figure 5E).
A potential role for SRF in regulating immediate early host gene expression in Toxoplasma-infected cells was examined by blocking SRF expression using gene-specific siRNAs.
TAM-dependent activation of the Cre-ERT2 led to an efficient, but not complete deletion of the SRF gene in skeletal muscle fibers, as revealed by the presence of a small proportion of immunostained nuclei for SRF in mutant myofibers.
To investigate the role for SRF in epidermal development and homeostasis, we conditionally knocked out SRF in epidermal keratinocytes.
Fundus photograph (a) of the left eye shows presence of subretinal fluid (SRF) in the macula.
Equiconvergence theorems are used to explain basis property of SRF in Lp-spaces and other rearrangement invariant function spaces.
This study investigates optical coherence tomography (OCT) in evaluating SRF in suspicious choroidal melanocytic tumors.
Horizontal (g) and vertical (h) cross-sectional OCT B-scan shows the presence of SRF in the macula.
