Sentence examples for src it from inspiring English sources
Since many of these are known targets of SRC, it is likely that SRC molecules activated by integrin receptor engagement, rather than SRC recruitment to CSF-1R, are responsible for these phosphorylation events.
Though the best performance is achieved by the SRC, it needs much computational time.
OP-SRC is designed on the decision rule of SRC, it aims to reduce the within-class reconstruction residual and simultaneously increase the between-class reconstruction residual on the training data.
In addition to Src, it is shown that phosphatidylinositol 3-kinase (phosphatidylinositol 3-kinaseecruitment of Rac to cell membrane [23].
Because at least some of these changes in gene expression occur downstream of signaling events (e.g., ERK, Src), it is possible that these signals are responsible for loss of syndecan-1 nuclear localization and resulting upregulation of gene transcription.
Based upon our understanding that there are likely multiple positive signaling inputs (signaling pathway crosstalk) along the Src, Stat3, Myc pathway (eg. Stat3 can also be activated by Jak2 in addition to Src), it seems desirable to suppress the pathway at multiple levels to achieve a maximal effect under a variety of cellular conditions.
Although integrins and G12/13 pathways activate c-Src, it is clear that this kinase has no significant role in thromboxane generation downstream of ADP receptors (Fig. 2C).
Although HER2 can activate c-Src, it is unclear if c-Src promotes proliferation.
The sequence identity between Btk and c-Abl is 42%, 31%, and 46% in the SH3, SH2, and kinase domains, respectively; for Btk and c-Src, it is 44%, 29%, and 40%.
Given the small size of the KIR2DL1-Cw6 complex, and the fact that signaling through KIR2DL1 is initiated by tyrosine phosphorylation of its cytoplasmic domain ITIM motif by Src kinases, it is plausible that KIR2DL1 signals through the kinetic-segregation mechanism.
Additionally, RasGRF1 is a substrate of the tyrosine kinase Src and it seems that oligomerization of RasGRFs is required for its biological functions [21].
