Sentence examples for sr leak from inspiring English sources

In addition, exercise normalized the diabetic-induced Ca2+ SR leak in cardiomyocytes from db/db mice (184) and STZ rats (176).

However, one could argue that an increased SR leak could also lower diastolic Ca due to the increase in NCX-mediated Ca extrusion in the subsarcolemmal space and increased Ca uptake by SERCA.

Additionally, we implemented parallel versions of the three test cases that include the putative CaMK induced diastolic SR leak according to the following equation: (6) This description of the leak sets, for example in the CaMK3X test case, about half a percent of the RyR channels to a constantly open state during diastole at 1 Hz pacing.

Previously, we showed that the rapid effect of BPA on cardiac arrhythmogenesis and mechanics is mediated by its impact on myocyte Ca2+ handling; in particular, increased diastolic SR leak plays a key role in the arrhythmogenic effect of BPA (Yan et al. 2011).

Therefore, K201 by inhibiting SR Ca2+ leak may improve SR Ca2+ load independently from pre-existing SERCA2 and NCX mechanisms.

TNF- α and IL-1 β increase the SR Ca2+ leak from the SR, which contributes to the depressed Ca2+ transient and contractility [ 39].

This finding is in agreement with studies showing that SR Ca2+ leak depends on sufficient SR Ca2+ load [ 29] and that extracellular Ca2+-depletion leads to reduced SR Ca2+ load and reduced SR Ca2+ leak [ 23].

(ii) An increased SR Ca leak could contribute to the lower SR Ca content measured.

Inhibition of CaMKII yielded a reduction of SR Ca2+ leak in human cardiomyocytes isolated from failing hearts and improved SR Ca2+ storage.

Furthermore, diabetic cardiomyocytes display increased SR Ca2+ leak through ryanodine receptors (RyR2) (184 184), which may contribute toward reducing SR Ca2+ content.

Increased SR Ca2+ leak and spontaneous Ca2+i waves also promote SDs.